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Figure 1
Pretreatment with curcumin inhibits cardiac hypertrophy in vitro. (A) Curcumin inhibited PE-induced [³H]leucine incorporation. (B) Representative fields of cardiac myocytes stained with α-actinin. Original magnification, ×200. (C) Quantification of cell cross-sectional area from experiments shown in B by measuring 50 random cells. (D) Curcumin blunted PE-induced ANP and BNP mRNA expression levels by Northern blot. [³H]leucine incorporation and Northern blot were measured as described in Methods. The results were reproducible in 3 separate experiments. *P < 0.05 versus control.