[HTML][HTML] Prolonged hypothermia causes primary nonfunction in preserved canine renal allografts due to humoral rejection
BJ Gilligan, HM Woo, M Kosieradzki… - American Journal of …, 2004 - Elsevier
Canine kidney preservation models have historically used autotransplants to avoid the
complications of rejection, although clinically all transplants are allografts. This study
investigated the effects of preservation time and method on early kidney function in a canine
allograft vs. autograft model. Kidneys were harvested from beagles, preserved by cold
storage (CS) in UW solution for 0, 24 or 72 h, or by machine perfusion (MP) with Belzer MPS
for 72 h. In some experiments 45 min of warm ischemia (WI) was performed in situ before …
complications of rejection, although clinically all transplants are allografts. This study
investigated the effects of preservation time and method on early kidney function in a canine
allograft vs. autograft model. Kidneys were harvested from beagles, preserved by cold
storage (CS) in UW solution for 0, 24 or 72 h, or by machine perfusion (MP) with Belzer MPS
for 72 h. In some experiments 45 min of warm ischemia (WI) was performed in situ before …