[HTML][HTML] Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells
BM Vanaudenaerde, WA Wuyts, N Geudens… - American Journal of …, 2007 - Elsevier
Lung transplantation is hampered by bronchiolitis obliterans syndrome (BOS), although
recently azithromycin treatment has a published response rate of about 42% in patients with
established BOS. We linked this improvement to a reduction in airway neutrophilia and IL8.
In the present study, we further investigated the intracellular mechanisms of azithromycin,
looking at the possible involvement of mitogen-activated-protein kinases (MAPK) and
oxidative stress. Simultaneously, currently used immunosuppressive agents were …
recently azithromycin treatment has a published response rate of about 42% in patients with
established BOS. We linked this improvement to a reduction in airway neutrophilia and IL8.
In the present study, we further investigated the intracellular mechanisms of azithromycin,
looking at the possible involvement of mitogen-activated-protein kinases (MAPK) and
oxidative stress. Simultaneously, currently used immunosuppressive agents were …