Type IV pili are not specifically required for contact dependent translocation of exoenzymes by Pseudomonas aeruginosa
C Sundin, MC Wolfgang, S Lory, Å Forsberg… - Microbial …, 2002 - Elsevier
The type III secretion system (TTSS) of the opportunistic pathogen Pseudomonas
aeruginosa enables the bacterium to deliver exoenzymes directly into the eukaryotic cell. In
this study we have investigated the role of key factors involved in this process. We could
demonstrate that the translocators PopB, PopD and PcrV are absolutely required for delivery
of Exoenzyme S into host cells. By analyzing different Tfp (type IV pili) mutants we could
establish a correlation between the frequency of bacteria binding to the host cell and the …
aeruginosa enables the bacterium to deliver exoenzymes directly into the eukaryotic cell. In
this study we have investigated the role of key factors involved in this process. We could
demonstrate that the translocators PopB, PopD and PcrV are absolutely required for delivery
of Exoenzyme S into host cells. By analyzing different Tfp (type IV pili) mutants we could
establish a correlation between the frequency of bacteria binding to the host cell and the …