Disruption of tumor necrosis factor-α gene diminishes the development of atherosclerosis in ApoE-deficient mice
H Ohta, H Wada, T Niwa, H Kirii, N Iwamoto, H Fujii… - Atherosclerosis, 2005 - Elsevier
Inflammatory cytokines, including tumor necrosis factor-α (TNF-α) have been implicated in
atherogenesis. However, the precise role of TNF-α in atherogenesis is still unclear. To
examine the effect of TNF-α on atherogenesis, we generated compound-deficient mice in
apolipoprotein E (apoE) and TNF-α (apoE−/−/TNF-α−/−) and compared them with apoE−/−
mice. Although serum total cholesterol levels were markedly elevated in both apoE−/−/TNF-
α−/− and apoE−/− mice compared to wild-type mice, no differences were observed between …
atherogenesis. However, the precise role of TNF-α in atherogenesis is still unclear. To
examine the effect of TNF-α on atherogenesis, we generated compound-deficient mice in
apolipoprotein E (apoE) and TNF-α (apoE−/−/TNF-α−/−) and compared them with apoE−/−
mice. Although serum total cholesterol levels were markedly elevated in both apoE−/−/TNF-
α−/− and apoE−/− mice compared to wild-type mice, no differences were observed between …