Control of nitric oxide production by transforming growth factor-β1: mechanistic insights and potential relevance to human disease
Y Vodovotz - Nitric oxide, 1997 - Elsevier
Studies on the multifunctional nature of the transforming growth factor-β (TGF-β) family of
cytokines and the enzyme nitric oxide synthase (NOS) have suggested that they mediate a
wide variety of vital processes in evolutionarily divergent organisms. Numerous mechanistic
studies have investigated the consequences of the regulation of NO by the TGF-β's for
mammalian physiology. Studies with several cell typesin vitroindicate that TGF-β1 negatively
controls the expression of the enzyme responsible for the prolonged production of large …
cytokines and the enzyme nitric oxide synthase (NOS) have suggested that they mediate a
wide variety of vital processes in evolutionarily divergent organisms. Numerous mechanistic
studies have investigated the consequences of the regulation of NO by the TGF-β's for
mammalian physiology. Studies with several cell typesin vitroindicate that TGF-β1 negatively
controls the expression of the enzyme responsible for the prolonged production of large …