Social stress alters the severity and onset of the chronic phase of Theiler's virus infection
RR Johnson, TW Prentice, P Bridegam… - Journal of …, 2006 - Elsevier
Social stress alters the acute phase of Theiler's virus infection (TMEV), a model of multiple
sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress
applied concurrent with infection was protective. The current study examined multiple
behavioral (motor impairment, open field activity) and immunological measures (IL-6,
antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It
was found that stress applied prior to infection exacerbated disease outcomes, while …
sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress
applied concurrent with infection was protective. The current study examined multiple
behavioral (motor impairment, open field activity) and immunological measures (IL-6,
antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It
was found that stress applied prior to infection exacerbated disease outcomes, while …