Stress susceptibility predicts the severity of immune depression and the failure to combat bacterial infections in chronically stressed mice
C Kiank, B Holtfreter, A Starke, A Mundt, C Wilke… - Brain, behavior, and …, 2006 - Elsevier
C Kiank, B Holtfreter, A Starke, A Mundt, C Wilke, C Schütt
Brain, behavior, and immunity, 2006•ElsevierChronic psychological stress has been suggested to play a role in disorders in which the
immune system unexpectedly fails to respond in a protective manner. Chronic combined
acoustic and restraint stress compromises the anti-bacterial defense mechanisms of female
BALB/c mice. The immunodeficiency is characterized by an apoptotic loss of lymphocytes,
reduced ex vivo-inducibility of TNF but increased inducibility of IL10, reduced T-cell
proliferation, and impaired phagocyte functions. Stressed mice develop depression-like …
immune system unexpectedly fails to respond in a protective manner. Chronic combined
acoustic and restraint stress compromises the anti-bacterial defense mechanisms of female
BALB/c mice. The immunodeficiency is characterized by an apoptotic loss of lymphocytes,
reduced ex vivo-inducibility of TNF but increased inducibility of IL10, reduced T-cell
proliferation, and impaired phagocyte functions. Stressed mice develop depression-like …
Chronic psychological stress has been suggested to play a role in disorders in which the immune system unexpectedly fails to respond in a protective manner. Chronic combined acoustic and restraint stress compromises the anti-bacterial defense mechanisms of female BALB/c mice. The immunodeficiency is characterized by an apoptotic loss of lymphocytes, reduced ex vivo-inducibility of TNF but increased inducibility of IL10, reduced T-cell proliferation, and impaired phagocyte functions. Stressed mice develop depression-like behavior that was monitored by a stress severity score (SSS). Besides a strain (BALB/c>CBA) and gender (male>female) dependent susceptibility to chronic stress, inbred mice have an individual coping ability. Importantly, the individual SSS strongly correlates with Escherichia coli dissemination after infection as well as with IL10-inducibility and circulating corticosterone levels of each animal.
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