Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders
Background A large number of skin diseases, including atopic dermatitis and psoriasis,
appear to be precipitated or exacerbated by psychological stress. Nevertheless, the specific
pathogenic role of psychological stress remains unknown. In 3different murine models of
psychological stress, it was recently shown thatpsychological stress negatively impacts
cutaneous permeability barrier functionand that coadministration of tranquilizers blocks this
stress-induced deteriorationin barrier function. Objectives and Methods The relationship …
appear to be precipitated or exacerbated by psychological stress. Nevertheless, the specific
pathogenic role of psychological stress remains unknown. In 3different murine models of
psychological stress, it was recently shown thatpsychological stress negatively impacts
cutaneous permeability barrier functionand that coadministration of tranquilizers blocks this
stress-induced deteriorationin barrier function. Objectives and Methods The relationship …