CRH stimulates POMC activity and corticosterone production in dermal fibroblasts
A Slominski, B Zbytek, I Semak, T Sweatman… - Journal of …, 2005 - Elsevier
It has been previously documented that human skin cells including epidermal keratinocytes
and dermal fibroblasts produce and process proopiomelanocortin (POMC), corticotropin
releasing hormone (CRH), and express functional CRH receptors type-1 (CRH-R1). The
skin also has corticosteroidogenic activity, suggesting a functional connection between
these elements. In the current study, we found that human dermal fibroblasts (but not normal
epidermal keratinocytes) respond to CRH with stimulation of cAMP, with POMC gene and …
and dermal fibroblasts produce and process proopiomelanocortin (POMC), corticotropin
releasing hormone (CRH), and express functional CRH receptors type-1 (CRH-R1). The
skin also has corticosteroidogenic activity, suggesting a functional connection between
these elements. In the current study, we found that human dermal fibroblasts (but not normal
epidermal keratinocytes) respond to CRH with stimulation of cAMP, with POMC gene and …