[HTML][HTML] Bisandrographolide from Andrographis paniculata activates TRPV4 channels
PL Smith, KN Maloney, RG Pothen, J Clardy… - Journal of Biological …, 2006 - ASBMB
Many transient receptor potential (TRP) channels are activated or blocked by various
compounds found in plants; two prominent examples include the activation of TRPV1
channels by capsaicin and the activation of TRPM8 channels by menthol. We sought to
identify additional plant compounds that are active on other types of TRP channels. We
screened a library of extracts from 50 Chinese herbal plants using a calcium-imaging assay
to find compounds active on TRPV3 and TRPV4 channels. An extract from the plant …
compounds found in plants; two prominent examples include the activation of TRPV1
channels by capsaicin and the activation of TRPM8 channels by menthol. We sought to
identify additional plant compounds that are active on other types of TRP channels. We
screened a library of extracts from 50 Chinese herbal plants using a calcium-imaging assay
to find compounds active on TRPV3 and TRPV4 channels. An extract from the plant …