[HTML][HTML] Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia
H Todaka, J Taniguchi, J Satoh, A Mizuno… - Journal of Biological …, 2004 - ASBMB
Animals sense various ranges of temperatures by cutaneous thermal stimuli. Transient
receptor potential vanilloid 4 (TRPV4) is a cation channel activated at a warm temperature
(over 30° C) in exogenously expressed cells. We found in the present study that TRPV4 is
essential in thermal hyperalgesia at a warm temperature in vivo. TRPV4–/–and TRPV4+/+
mice exhibited the same latency of escape from 35–50° C hotplates. Neuronal activity in the
femoral nerve, however, revealed that the number and activity level of neurons decreased in …
receptor potential vanilloid 4 (TRPV4) is a cation channel activated at a warm temperature
(over 30° C) in exogenously expressed cells. We found in the present study that TRPV4 is
essential in thermal hyperalgesia at a warm temperature in vivo. TRPV4–/–and TRPV4+/+
mice exhibited the same latency of escape from 35–50° C hotplates. Neuronal activity in the
femoral nerve, however, revealed that the number and activity level of neurons decreased in …