[HTML][HTML] Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
H Watanabe, JB Davis, D Smart, JC Jerman… - Journal of Biological …, 2002 - ASBMB
We have studied activation by phorbol derivatives of TRPV4 channels, the human VRL-2,
and murine TRP12 channels, which are highly homologous to the human VR-OAC, and the
human and murine OTRPC4 channel. 4α-Phorbol 12, 13-didecanoate (4α-PDD) induced an
increase in intracellular Ca 2+ concentration,[Ca 2+] i, in 1321N1 cells stably transfected
with human VRL-2 (hVRL-2.1321 N1) or HEK-293 cells transiently transfected with murine
TRP12, but not in nontransfected or mock-transfected cells. Concomitantly with the increase …
and murine TRP12 channels, which are highly homologous to the human VR-OAC, and the
human and murine OTRPC4 channel. 4α-Phorbol 12, 13-didecanoate (4α-PDD) induced an
increase in intracellular Ca 2+ concentration,[Ca 2+] i, in 1321N1 cells stably transfected
with human VRL-2 (hVRL-2.1321 N1) or HEK-293 cells transiently transfected with murine
TRP12, but not in nontransfected or mock-transfected cells. Concomitantly with the increase …