[HTML][HTML] Oxidant hypersensitivity of Fanconi anemia type C-deficient cells is dependent on a redox-regulated apoptotic pathway
MR Saadatzadeh, K Bijangi-Vishehsaraei… - Journal of Biological …, 2004 - ASBMB
Fanconi anemia is a genetic disorder characterized by bone marrow failure. Significant
evidence supports enhanced apoptosis of hematopoietic stem/progenitor cells as a critical
factor in the pathogenesis of bone marrow failure in Fanconi anemia. However, the
molecular mechanism (s) responsible for the apoptotic phenotype are incompletely
understood. Here, we tested whether alterations in the activation of a redox-dependent
pathway may participate in the pro-apoptotic phenotype of primary Fancc-/-cells in response …
evidence supports enhanced apoptosis of hematopoietic stem/progenitor cells as a critical
factor in the pathogenesis of bone marrow failure in Fanconi anemia. However, the
molecular mechanism (s) responsible for the apoptotic phenotype are incompletely
understood. Here, we tested whether alterations in the activation of a redox-dependent
pathway may participate in the pro-apoptotic phenotype of primary Fancc-/-cells in response …