Physiological roles of muscle-derived interleukin-6 in response to exercise
BK Pedersen, CP Fischer - Current Opinion in Clinical Nutrition & …, 2007 - journals.lww.com
Current Opinion in Clinical Nutrition & Metabolic Care, 2007•journals.lww.com
The discovery of contracting muscle as a cytokine-producing organ opens a new paradigm:
skeletal muscle is an endocrine organ that in response to contractions produces and
releases 'myokines', which subsequently can modulate the metabolic and immunological
response to exercise in several tissues. In our view, interleukin-6 may be one of several
myokines.
skeletal muscle is an endocrine organ that in response to contractions produces and
releases 'myokines', which subsequently can modulate the metabolic and immunological
response to exercise in several tissues. In our view, interleukin-6 may be one of several
myokines.
Summary
The discovery of contracting muscle as a cytokine-producing organ opens a new paradigm: skeletal muscle is an endocrine organ that in response to contractions produces and releases ‘myokines’, which subsequently can modulate the metabolic and immunological response to exercise in several tissues. In our view, interleukin-6 may be one of several myokines.
Lippincott Williams & Wilkins