Diversity of gene expression in adenocarcinoma of the lung
ME Garber, OG Troyanskaya… - Proceedings of the …, 2001 - National Acad Sciences
ME Garber, OG Troyanskaya, K Schluens, S Petersen, Z Thaesler, M Pacyna-Gengelbach…
Proceedings of the National Academy of Sciences, 2001•National Acad SciencesThe global gene expression profiles for 67 human lung tumors representing 56 patients
were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors
based on gene expression patterns faithfully recapitulated morphological classification of
the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression
patterns made possible the subclassification of adenocarcinoma into subgroups that
correlated with the degree of tumor differentiation as well as patient survival. Gene …
were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors
based on gene expression patterns faithfully recapitulated morphological classification of
the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression
patterns made possible the subclassification of adenocarcinoma into subgroups that
correlated with the degree of tumor differentiation as well as patient survival. Gene …
The global gene expression profiles for 67 human lung tumors representing 56 patients were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors based on gene expression patterns faithfully recapitulated morphological classification of the tumors into squamous, large cell, small cell, and adenocarcinoma. The gene expression patterns made possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival. Gene expression analysis thus promises to extend and refine standard pathologic analysis.
National Acad Sciences