Targeted therapy in combination with gemcitabine in non-small cell lung cancer
R Rosell, L Crino, K Danenberg, G Scagliotti… - Seminars in …, 2003 - Elsevier
Gemcitabine (Gemzar; Eli Lilly and Company, Indianapolis, IN) and cisplatin are commonly
used in the treatment of many solid tumors, although the impact of chemotherapy is limited in
metastatic non-small cell lung cancer. However, in clinical practice, there is a minority of
patients who can attain long-term survival. Upregulation of mRNA transcripts has been
linked to chemoresistance, and in some instances, mRNA expression has been correlated
with polymorphisms. Cisplatin resistance is directly linked to the nucleotide excision repair …
used in the treatment of many solid tumors, although the impact of chemotherapy is limited in
metastatic non-small cell lung cancer. However, in clinical practice, there is a minority of
patients who can attain long-term survival. Upregulation of mRNA transcripts has been
linked to chemoresistance, and in some instances, mRNA expression has been correlated
with polymorphisms. Cisplatin resistance is directly linked to the nucleotide excision repair …