WNK1 affects surface expression of the ROMK potassium channel independent of WNK4
G Cope, M Murthy, AP Golbang, A Hamad… - Journal of the …, 2006 - journals.lww.com
The WNK (with no lysine kinase) kinases are a novel class of serine/threonine kinases that
lack a characteristic lysine residue for ATP docking. Both WNK1 and WNK4 are expressed in
the mammalian kidney, and mutations in either can cause the rare familial syndrome of
hypertension and hyperkalemia (Gordon syndrome, or pseudohypoaldosteronism type 2).
The molecular basis for the action of WNK4 is through alteration in the membrane
expression of the NaCl co-transporter (NCCT) and the renal outer-medullary K channel …
lack a characteristic lysine residue for ATP docking. Both WNK1 and WNK4 are expressed in
the mammalian kidney, and mutations in either can cause the rare familial syndrome of
hypertension and hyperkalemia (Gordon syndrome, or pseudohypoaldosteronism type 2).
The molecular basis for the action of WNK4 is through alteration in the membrane
expression of the NaCl co-transporter (NCCT) and the renal outer-medullary K channel …