A ubiquitous pathway for cellular Ca2+ influx involves 'store-operated channels' that
respond to depletion of intracellular Ca2+ pools via an as yet unknown mechanism. Due to
its wide-spread expression, store-operated Ca2+ entry (SOCE) has been considered a
principal route for Ca2+ influx. However, recent evidence has suggested that alternative
pathways, activated for example by lipid metabolites, are responsible for physiological Ca2+
influx. It is not clear if these messenger-activated Ca2+ entry routes exist in all cells and what …