[HTML][HTML] Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis
M Horiuchi, T Yamada, W Hayashida… - Journal of Biological …, 1997 - ASBMB
The expression of the angiotensin II type 2 (AT 2) receptor is developmentally and growth
regulated. In cultured R3T3 cells, expression of this receptor is markedly induced at the
confluent state and with serum deprivation. In this study we demonstrated that the removal of
serum from culture media resulted in the induction of apoptosis in these cells and the
addition of angiotensin II further enhanced apoptosis. We have previously identified an
interferon regulatory factor (IRF) binding motif in the mouse AT 2 receptor gene promoter …
regulated. In cultured R3T3 cells, expression of this receptor is markedly induced at the
confluent state and with serum deprivation. In this study we demonstrated that the removal of
serum from culture media resulted in the induction of apoptosis in these cells and the
addition of angiotensin II further enhanced apoptosis. We have previously identified an
interferon regulatory factor (IRF) binding motif in the mouse AT 2 receptor gene promoter …
