Intracellular third loop domain of angiotensin II type-2 receptor: role in mediating signal transduction and cellular function
W Hayashida, M Horiuchi, VJ Dzau - Journal of Biological Chemistry, 1996 - ASBMB
The present study tests the hypothesis that the unique intracellular third loop domain of
angiotensin II type-2 (AT2) receptor is essential for the subsequent intracellular signaling
and plays an important role in mediating receptor function. Synthetic intracellular third loop
peptide of the AT2 receptor (AT2-3LP, 22 amino acids) and control peptide consisting of the
same amino acid composition in random sequence were delivered into adult rat aortic
vascular smooth muscle cells by cationic liposome-mediated transfection. Successful …
angiotensin II type-2 (AT2) receptor is essential for the subsequent intracellular signaling
and plays an important role in mediating receptor function. Synthetic intracellular third loop
peptide of the AT2 receptor (AT2-3LP, 22 amino acids) and control peptide consisting of the
same amino acid composition in random sequence were delivered into adult rat aortic
vascular smooth muscle cells by cationic liposome-mediated transfection. Successful …