Tissue-specific stabilization of the thyroid hormone β1 nuclear receptor by phosphorylation
YT Ting, MK Bhat, R Wong, S Cheng - Journal of Biological Chemistry, 1997 - ASBMB
The present study evaluated the expression and regulation of endogenous thyroid hormone
receptors (TRs) in cultured cells. In COS-1 cells, the endogenous TR, subtype β1 (TRβ1), but
not subtype β2 or α1, was induced to express by okadaic acid (OA) in a concentration-
dependent manner. The induced TRβ1 had immunoreactivity and partial V8 proteolytic
maps similar to those of the transfected and in vitro translated human TRβ1 (h-TRβ1). The
OA-induced expression of endogenous TRβ1 was, however, not observed in a variety of …
receptors (TRs) in cultured cells. In COS-1 cells, the endogenous TR, subtype β1 (TRβ1), but
not subtype β2 or α1, was induced to express by okadaic acid (OA) in a concentration-
dependent manner. The induced TRβ1 had immunoreactivity and partial V8 proteolytic
maps similar to those of the transfected and in vitro translated human TRβ1 (h-TRβ1). The
OA-induced expression of endogenous TRβ1 was, however, not observed in a variety of …
