Evaluation of monoclonal antibodies having specificity for human IgG sub-classes: results of an IUIS/WHO collaborative study
R Jefferis, CB Reimer, F Skvaril, G De Lange, NR Ling… - Immunology letters, 1985 - Elsevier
Seventy-four monoclonal antibodies (McAb) of putative specificity for human IgG (11), the
IgG subclasses (59) or Gm allotypes (4) have been evaluated for reactivity and specificity in
eight laboratories employing different assay techniques or protocols. For the IgG, IgG3, IgG4,
G1m (f) and G3m (u) specificities McAb have been produced that can be satisfactorily
applied in most methodologies employed and have potential as reference reagents. The
IgG1 and particularly IgG2 specificities proved problematical with all McAb evaluated …
IgG subclasses (59) or Gm allotypes (4) have been evaluated for reactivity and specificity in
eight laboratories employing different assay techniques or protocols. For the IgG, IgG3, IgG4,
G1m (f) and G3m (u) specificities McAb have been produced that can be satisfactorily
applied in most methodologies employed and have potential as reference reagents. The
IgG1 and particularly IgG2 specificities proved problematical with all McAb evaluated …