Oncolytic virotherapy: approaches to tumor targeting and enhancing antitumor effects
SH Thorne, T Hermiston, D Kirn - Seminars in oncology, 2005 - Elsevier
The application of replicating viruses for the treatment of cancers represents a novel therapy
that is distinct from traditional treatment modalities. It is apparent that the genetic changes
that a virus produces within an infected cell in order to create an environment conducive to
viral replication are often similar to the processes involved in cellular transformation. These
include uncontrolled cellular proliferation, prevention of apoptosis, and resistance to host
organism immune effector mechanisms. Deletions of viral genes involved in these …
that is distinct from traditional treatment modalities. It is apparent that the genetic changes
that a virus produces within an infected cell in order to create an environment conducive to
viral replication are often similar to the processes involved in cellular transformation. These
include uncontrolled cellular proliferation, prevention of apoptosis, and resistance to host
organism immune effector mechanisms. Deletions of viral genes involved in these …