[HTML][HTML] Regulation of Cl−/HCO3− exchange by cystic fibrosis transmembrane conductance regulator expressed in NIH 3T3 and HEK 293 cells
A central function of cystic fibrosis transmembrane conductance regulator (CFTR)-
expressing tissues is the secretion of fluid containing 100–140 mmHCO 3−. High levels of
HCO 3− maintain secreted proteins such as mucins (all tissues) and digestive enzymes
(pancreas) in a soluble and/or inactive state. HCO 3− secretion is impaired in CF in all CFTR-
expressing, HCO 3−-secreting tissues examined. The mechanism responsible for this critical
problem in CF is unknown. Since a major component of HCO 3− secretion in CFTR …
expressing tissues is the secretion of fluid containing 100–140 mmHCO 3−. High levels of
HCO 3− maintain secreted proteins such as mucins (all tissues) and digestive enzymes
(pancreas) in a soluble and/or inactive state. HCO 3− secretion is impaired in CF in all CFTR-
expressing, HCO 3−-secreting tissues examined. The mechanism responsible for this critical
problem in CF is unknown. Since a major component of HCO 3− secretion in CFTR …