[HTML][HTML] Efficient endocytosis of the cystic fibrosis transmembrane conductance regulator requires a tyrosine-based signal
LS Prince, K Peter, SR Hatton, L Zaliauskiene… - Journal of Biological …, 1999 - ASBMB
We previously demonstrated that the cystic fibrosis transmembrane conductance regulator
(CFTR) is rapidly endocytosed in epithelial cells (Prince, LS, Workman, RB, Jr., and
Marchase, RB (1994) Proc. Natl. Acad. Sci. USA 91, 5192–5196). To determine the
structural features of CFTR required for endocytosis, we prepared chimeric molecules
consisting of the amino-terminal (residues 2–78) and carboxyl-terminal tail regions (residues
1391–1476) of CFTR, each fused to the transmembrane and extracellular domains of the …
(CFTR) is rapidly endocytosed in epithelial cells (Prince, LS, Workman, RB, Jr., and
Marchase, RB (1994) Proc. Natl. Acad. Sci. USA 91, 5192–5196). To determine the
structural features of CFTR required for endocytosis, we prepared chimeric molecules
consisting of the amino-terminal (residues 2–78) and carboxyl-terminal tail regions (residues
1391–1476) of CFTR, each fused to the transmembrane and extracellular domains of the …