In recent years, immunohistochemistry has assumed an increasingly prominent role in
diagnostic breast pathology. Immunohistochemistry is now frequently used in the evaluation
of many epithelial proliferations of the breast. Common applications include the use of
myoepithelial markers to evaluate for stromal invasion, E-cadherin to distinguish between
ductal and lobular neoplasia, high molecular weight cytokeratins to differentiate usual ductal
hyperplasia from ductal carcinoma in situ, immunohistochemical profiles to characterize site …