Homocysteine stimulates the production and secretion of cholesterol in hepatic cells
O Karmin, EG Lynn, YH Chung, YL Siow… - … et Biophysica Acta (BBA …, 1998 - Elsevier
Homocysteinemia and hypercholesterolemia are important risk factors associated with the
occurrence of arteriosclerotic vascular diseases. A positive correlation between plasma
levels of homocysteine and cholesterol was found in homocysteinemic patients as well as in
experimental animals. In the present study, the effect of homocysteine on the production and
secretion of cholesterol in human hepatoma cell line HepG2 cells was investigated. When
cells were incubated with 4 mM homocysteine, the amounts of total cholesterol produced as …
occurrence of arteriosclerotic vascular diseases. A positive correlation between plasma
levels of homocysteine and cholesterol was found in homocysteinemic patients as well as in
experimental animals. In the present study, the effect of homocysteine on the production and
secretion of cholesterol in human hepatoma cell line HepG2 cells was investigated. When
cells were incubated with 4 mM homocysteine, the amounts of total cholesterol produced as …