[HTML][HTML] Endoplasmic reticulum stress proteins block oxidant-induced Ca2+ increases and cell death
H Liu, E Miller, B van de Water, JL Stevens - Journal of Biological Chemistry, 1998 - ASBMB
Oxidants are important human toxicants. Increased intracellular free Ca 2+ may be critical for
oxidant toxicity, but this mechanism remains controversial. Furthermore, oxidants damage
the endoplasmic reticulum (ER) and release ER Ca 2+, but the role of the ER in oxidant
toxicity and Ca 2+ regulation during toxicity is also unclear. tert-Butylhydroperoxide (TBHP),
a prototypical organic oxidant, causes oxidative stress and an increase in intracellular free
Ca 2+. Therefore, we addressed the mechanism of oxidant-induced cell death and …
oxidant toxicity, but this mechanism remains controversial. Furthermore, oxidants damage
the endoplasmic reticulum (ER) and release ER Ca 2+, but the role of the ER in oxidant
toxicity and Ca 2+ regulation during toxicity is also unclear. tert-Butylhydroperoxide (TBHP),
a prototypical organic oxidant, causes oxidative stress and an increase in intracellular free
Ca 2+. Therefore, we addressed the mechanism of oxidant-induced cell death and …