Requirement of IE Molecule for Thymocyte Apoptosis Induced by Staphylococcal Enterotoxin Bin Vivo
YS Lin, YT Huang, PS Chen, CF Lin, MS Jan, HY Lei - Cellular immunology, 1999 - Elsevier
In vivoadministration of bacterial superantigen staphylococcal enterotoxin B (SEB) to BALB/c
mice led to thymus atrophy resulting from thymocyte apoptosis. In this study, we
demonstrated that SEB induced a substantial reduction in thymocyte numbers in BALB/c,
B10. D2 (H-2dhaplotype), B10. BR, C3H/HeJ, C3H/HeN (H-2k), and (BALB/c× B6) F1 (H-
2dxb), but caused little or no effect in IE− strains such as B6, B10, A. BY (H-2b), and A. SW
(H-2s) mice. Elimination of CD4+ CD8+ cells predominantly accounted for the thymocyte …
mice led to thymus atrophy resulting from thymocyte apoptosis. In this study, we
demonstrated that SEB induced a substantial reduction in thymocyte numbers in BALB/c,
B10. D2 (H-2dhaplotype), B10. BR, C3H/HeJ, C3H/HeN (H-2k), and (BALB/c× B6) F1 (H-
2dxb), but caused little or no effect in IE− strains such as B6, B10, A. BY (H-2b), and A. SW
(H-2s) mice. Elimination of CD4+ CD8+ cells predominantly accounted for the thymocyte …