A firm base for drug development
B De Strooper, G König - Nature, 1999 - nature.com
B De Strooper, G König
Nature, 1999•nature.comAlzheimer's disease is a progressive dementia in which massive protein deposits
accumulate as either amyloid plaques or neurofibrillary tangles. The plaques are composed
of a peptide called Aβ, which is liberated from its precursor, the amyloid precursor protein, by
cleavage at two sites. The enzyme that cleaves at one of these sites, the β site, has now
been identified, and it is likely to be a good target for drugs.
accumulate as either amyloid plaques or neurofibrillary tangles. The plaques are composed
of a peptide called Aβ, which is liberated from its precursor, the amyloid precursor protein, by
cleavage at two sites. The enzyme that cleaves at one of these sites, the β site, has now
been identified, and it is likely to be a good target for drugs.
Alzheimer's disease is a progressive dementia in which massive protein deposits accumulate as either amyloid plaques or neurofibrillary tangles. The plaques are composed of a peptide called Aβ, which is liberated from its precursor, the amyloid precursor protein, by cleavage at two sites. The enzyme that cleaves at one of these sites, the β site, has now been identified, and it is likely to be a good target for drugs.
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