Although sodium retention is a common coplication in advanced liver disease, the
relationship between liver and kidney function in cirrhosis has not been well established.
The objective of this study was to investigate this relationship in an experimental model of
cirrhosis induced in phenobarbital–treated rats by weekly intragatric adminstration of carbon
terachloride. Liver function, measured by the aminopyrine breath test, and urinary sodium
excretion on a constant salt diet, were measured weekly. Administation of carbon …