Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
L Alland, R Muhle, H Hou Jr, J Potes, L Chin… - Nature, 1997 - nature.com
L Alland, R Muhle, H Hou Jr, J Potes, L Chin, N Schreiber-Agus, RA DePinho
Nature, 1997•nature.comNormal mammalian growth and development are highly dependent on the regulation of the
expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of
Myc activities requires interaction with mammalian Sln3A or Sin3B proteins, which have
been purported to act as scaffolds for additional co-repressor factors. The identification of
two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone
deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and …
expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of
Myc activities requires interaction with mammalian Sln3A or Sin3B proteins, which have
been purported to act as scaffolds for additional co-repressor factors. The identification of
two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone
deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and …
Abstract
Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sln3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.
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