Signaling by distinct classes of phosphoinositide 3-kinases
B Vanhaesebroeck, MD Waterfield - Experimental cell research, 1999 - Elsevier
B Vanhaesebroeck, MD Waterfield
Experimental cell research, 1999•ElsevierMany signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K)
enzymes whose inositol lipid products are key mediators of intracellular signaling. Different
PI3K isoforms generate specific lipids that bind to FYVE and pleckstrin homology (PH)
domains in a variety of proteins, affecting their localization, conformation, and activities. Here
we review the activation mechanisms of the different types of PI3Ks and their downstream
actions, with focus on the PI3Ks that are acutely triggered by extracellular stimulation.
enzymes whose inositol lipid products are key mediators of intracellular signaling. Different
PI3K isoforms generate specific lipids that bind to FYVE and pleckstrin homology (PH)
domains in a variety of proteins, affecting their localization, conformation, and activities. Here
we review the activation mechanisms of the different types of PI3Ks and their downstream
actions, with focus on the PI3Ks that are acutely triggered by extracellular stimulation.
Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K) enzymes whose inositol lipid products are key mediators of intracellular signaling. Different PI3K isoforms generate specific lipids that bind to FYVE and pleckstrin homology (PH) domains in a variety of proteins, affecting their localization, conformation, and activities. Here we review the activation mechanisms of the different types of PI3Ks and their downstream actions, with focus on the PI3Ks that are acutely triggered by extracellular stimulation.
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