C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen,
oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio
groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same
carbon skeletonC07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted
by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to …

The recent development of farnesyltransferase inhibitors which inhibit the growth of RAS-
transformed cells demonstrates that membrane association of RAS and other monomeric G
proteins such as Rho is important for the tumorigenicity of RAS. 1–3 In the early 1980s, it
was established that RAS is C-terminally modified and that this modification is important for
both its membrane association and tumorigenicity. This observation was followed by the
elucidation of the steps involved in the C-terminal modification. The first step in this …