[HTML][HTML] Reactivation of peroxisome proliferator-activated receptor α is associated with contractile dysfunction in hypertrophied rat heart
ME Young, FA Laws, GW Goodwin… - Journal of Biological …, 2001 - ASBMB
In pressure overload-induced hypertrophy, the heart increases its reliance on glucose as a
fuel while decreasing fatty acid oxidation. A key regulator of this substrate switching in the
hypertrophied heart is peroxisome proliferator-activated receptor α (PPARα). We tested the
hypothesis that down-regulation of PPARα is an essential component of cardiac hypertrophy
at the levels of increased mass, gene expression, and metabolism by pharmacologically
reactivating PPARα. Pressure overload (induced by constriction of the ascending aorta for 7 …
fuel while decreasing fatty acid oxidation. A key regulator of this substrate switching in the
hypertrophied heart is peroxisome proliferator-activated receptor α (PPARα). We tested the
hypothesis that down-regulation of PPARα is an essential component of cardiac hypertrophy
at the levels of increased mass, gene expression, and metabolism by pharmacologically
reactivating PPARα. Pressure overload (induced by constriction of the ascending aorta for 7 …