[HTML][HTML] Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells
Peroxisome proliferator-activated receptor γ coactivator (PGC)-1α is a coactivator of nuclear
receptors and other transcription factors that regulates several components of energy
metabolism, particularly certain aspects of adaptive thermogenesis in brown fat and skeletal
muscle, hepatic gluconeogenesis, and fiber type switching in skeletal muscle. PGC-1α has
been shown to induce mitochondrial biogenesis when expressed in muscle cells, and
preliminary analysis has suggested that this molecule may specifically increase the fraction …
receptors and other transcription factors that regulates several components of energy
metabolism, particularly certain aspects of adaptive thermogenesis in brown fat and skeletal
muscle, hepatic gluconeogenesis, and fiber type switching in skeletal muscle. PGC-1α has
been shown to induce mitochondrial biogenesis when expressed in muscle cells, and
preliminary analysis has suggested that this molecule may specifically increase the fraction …