[HTML][HTML] Adenovirus E1A Represses Cardiac Gene Transcription and Reactivates DNA Synthesis in Ventricular Myocytes, via Alternative Pocket Protein-and p300 …
LA Kirshenbaum, MD Schneider - Journal of Biological Chemistry, 1995 - ASBMB
To examine the potential impact of disrupting" pocket" protein function on cardiac
differentiation and growth, we introduced 12 S E1A genes into neonatal ventricular
myocytes, by adenoviral gene transfer. In the absence of E1B, E1A was cytotoxic, with
features typical of apoptosis. In the presence of E1B, E1A preferentially inhibited
transcription of cardiac-restricted α-actin promoters, and reactivated DNA synthesis in
cardiac myocytes, without cell death. Mutations that abrogate known activities of the amino …
differentiation and growth, we introduced 12 S E1A genes into neonatal ventricular
myocytes, by adenoviral gene transfer. In the absence of E1B, E1A was cytotoxic, with
features typical of apoptosis. In the presence of E1B, E1A preferentially inhibited
transcription of cardiac-restricted α-actin promoters, and reactivated DNA synthesis in
cardiac myocytes, without cell death. Mutations that abrogate known activities of the amino …
