[HTML][HTML] Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model

T Tanaka, I Kojima, T Ohse, JR Ingelfinger, S Adler… - Laboratory …, 2005 - Elsevier
Tubulointerstitial hypoxia has been implicated in a number of progressive renal diseases,
and several lines of evidence indicate that the administration of angiogenic growth factors
ameliorates tubulointerstitial injury. We hypothesized that induction of hypoxia-inducible
factors (HIF) mediates renoprotection by their angiogenic properties. At 5–9 weeks after
subtotal nephrectomy, cobalt was administered to rats to activate HIF. Histological
evaluation demonstrated that the tubulointerstitial injury was significantly ameliorated in …