Interstitial vascular rarefaction and reduced VEGF-A expression in human diabetic nephropathy

MT Lindenmeyer, M Kretzler, A Boucherot… - Journal of the …, 2007 - journals.lww.com
Diabetic nephropathy (DN) is a frequent complication in patients with diabetes. Although the
majority of DN models and human studies have focused on glomeruli, tubulointerstitial
damage is a major feature of DN and an important predictor of renal dysfunction. This study
sought to investigate molecular markers of pathogenic pathways in the renal interstitium of
patients with DN. Microdissected tubulointerstitial compartments from biopsies with
established DN and control kidneys were subjected to expression profiling. Analysis of …