[HTML][HTML] Regulation of the hypoxia-inducible factor 1α by the inflammatory mediators nitric oxide and tumor necrosis factor-α in contrast to desferroxamine and …
KB Sandau, J Zhou, T Kietzmann, B Brüne - Journal of Biological …, 2001 - ASBMB
Hypoxic/ischemic conditions provoke activation of the hypoxia-inducible factor-1 (HIF-1),
which functions as a transcription factor. HIF-1 is composed of the HIF-1α and-β subunits,
and stability regulation occurs via accumulation/degradation of HIF-1α with the notion that a
prolyl hydroxylase accounts for changes in protein level. In addition, there is evidence that
HIF-1 is up-regulated by diverse agonists during normoxia. We investigated the impact of
inflammatory mediators nitric oxide (NO) and tumor necrosis factor-α (TNF-α) on HIF-1α …
which functions as a transcription factor. HIF-1 is composed of the HIF-1α and-β subunits,
and stability regulation occurs via accumulation/degradation of HIF-1α with the notion that a
prolyl hydroxylase accounts for changes in protein level. In addition, there is evidence that
HIF-1 is up-regulated by diverse agonists during normoxia. We investigated the impact of
inflammatory mediators nitric oxide (NO) and tumor necrosis factor-α (TNF-α) on HIF-1α …