[HTML][HTML] Cell migration and signaling specificity is determined by the phosphatidylserine recognition motif of Rac1
The Rho guanosine triphosphatases (GTPases) control cell shape and motility and are
frequently overexpressed during malignant growth. These proteins act as molecular
switches cycling between active GTP-and inactive GDP-bound forms. Despite being
membrane anchored via their isoprenylated C termini, Rho GTPases rapidly translocate
between membrane and cytosolic compartments. Here, we show that the Rho GTPase Rac1
preferentially interacts with phosphatidylserine (PS)-containing bilayers through its …
frequently overexpressed during malignant growth. These proteins act as molecular
switches cycling between active GTP-and inactive GDP-bound forms. Despite being
membrane anchored via their isoprenylated C termini, Rho GTPases rapidly translocate
between membrane and cytosolic compartments. Here, we show that the Rho GTPase Rac1
preferentially interacts with phosphatidylserine (PS)-containing bilayers through its …