[HTML][HTML] Hepatocyte nuclear factor-4 controls transcription from a TATA-less human sex hormone-binding globulin gene promoter
M Jänne, GL Hammond - Journal of Biological Chemistry, 1998 - ASBMB
Hepatocytes are the major source of sex hormone-binding globulin (SHBG), a glycoprotein
that transports sex steroids in the blood and regulates their access to target tissues. The
human SHBGproximal promoter was analyzed by DNase I footprinting, and the functional
significance of 6 footprinted regions (FP1–FP6) within the proximal promoter was studied in
human HepG2 hepatoblastoma cells. Two footprinted regions (FP1 and FP3) contain
binding sites for the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) …
that transports sex steroids in the blood and regulates their access to target tissues. The
human SHBGproximal promoter was analyzed by DNase I footprinting, and the functional
significance of 6 footprinted regions (FP1–FP6) within the proximal promoter was studied in
human HepG2 hepatoblastoma cells. Two footprinted regions (FP1 and FP3) contain
binding sites for the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) …