[HTML][HTML] A human sex hormone-binding globulin isoform accumulates in the acrosome during spermatogenesis
DM Selva, KN Hogeveen, K Seguchi, F Tekpetey… - Journal of Biological …, 2002 - ASBMB
Human sex hormone-binding globulin (SHBG) binds estradiol and testosterone with high
affinity. Plasma SHBG is produced by hepatocytes, but the human SHBG gene is also
expressed in the testis. Little is known about SHBG gene expression in the human testis, but
human SHBG transcripts accumulate in a spermatogenic stage-dependent manner in the
testes of mice containing an 11-kb human SHBG transgene. We have now found that human
SHBG transcripts containing an alternative exon 1 sequence are located specifically in the …
affinity. Plasma SHBG is produced by hepatocytes, but the human SHBG gene is also
expressed in the testis. Little is known about SHBG gene expression in the human testis, but
human SHBG transcripts accumulate in a spermatogenic stage-dependent manner in the
testes of mice containing an 11-kb human SHBG transgene. We have now found that human
SHBG transcripts containing an alternative exon 1 sequence are located specifically in the …