[HTML][HTML] Repression of the human sex hormone-binding globulin gene in Sertoli cells by upstream stimulatory transcription factors
DM Selva, KN Hogeveen, GL Hammond - Journal of Biological Chemistry, 2005 - ASBMB
Expression of the sex hormone-binding globulin gene (SHBG) in the liver produces SHBG,
which transports sex steroids in the blood. In rodents, the SHBG gene is also expressed in
Sertoli cells giving rise to the testicular androgen-binding protein, which is secreted into the
seminiferous tubule where it presumably controls testosterone action. Evidence that the
SHBG gene functions in this way in the human testis is lacking, and mice containing a
human SHBG transgene (shbg4) under the control of its own promoter sequence are …
which transports sex steroids in the blood. In rodents, the SHBG gene is also expressed in
Sertoli cells giving rise to the testicular androgen-binding protein, which is secreted into the
seminiferous tubule where it presumably controls testosterone action. Evidence that the
SHBG gene functions in this way in the human testis is lacking, and mice containing a
human SHBG transgene (shbg4) under the control of its own promoter sequence are …