[HTML][HTML] Degradation of p27Kip1 at the G0-G1 transition mediated by a Skp2-independent ubiquitination pathway
T Hara, T Kamura, K Nakayama, K Oshikawa… - Journal of Biological …, 2001 - ASBMB
Targeting of the cyclin-dependent kinase inhibitor p27 Kip1 for proteolysis has been thought
to be mediated by Skp2, the F-box protein component of an SCF ubiquitin ligase complex.
Degradation of p27 Kip1 at the G 0-G 1 transition of the cell cycle has now been shown to
proceed normally inSkp2−/− lymphocytes, whereas p27 Kip1 proteolysis during SG 2
phases is impaired in these Skp2-deficient cells. Degradation of p27 Kip1 at the G 0-G 1
transition was blocked by lactacystin, a specific proteasome inhibitor, suggesting that it is …
to be mediated by Skp2, the F-box protein component of an SCF ubiquitin ligase complex.
Degradation of p27 Kip1 at the G 0-G 1 transition of the cell cycle has now been shown to
proceed normally inSkp2−/− lymphocytes, whereas p27 Kip1 proteolysis during SG 2
phases is impaired in these Skp2-deficient cells. Degradation of p27 Kip1 at the G 0-G 1
transition was blocked by lactacystin, a specific proteasome inhibitor, suggesting that it is …