[HTML][HTML] Isoprenoids as mediators of the biological effects of statins
JK Liao - The Journal of clinical investigation, 2002 - Am Soc Clin Investig
The Journal of clinical investigation, 2002•Am Soc Clin Investig
Trial (MRFIT) demonstrated significant correlation between ischemic stroke and serum
cholesterol levels (13, 14). Thus, the findings of these large statin trials raise the interesting
question of how statins could reduce ischemic stroke when ischemic stroke and cholesterol
are unrelated. It appears likely that some of the beneficial effects of statins in ischemic stroke
are attributable to the pleiotropic effects of statins on endothelial function and fibrinolytic
pathways.
cholesterol levels (13, 14). Thus, the findings of these large statin trials raise the interesting
question of how statins could reduce ischemic stroke when ischemic stroke and cholesterol
are unrelated. It appears likely that some of the beneficial effects of statins in ischemic stroke
are attributable to the pleiotropic effects of statins on endothelial function and fibrinolytic
pathways.
Trial (MRFIT) demonstrated significant correlation between ischemic stroke and serum cholesterol levels (13, 14). Thus, the findings of these large statin trials raise the interesting question of how statins could reduce ischemic stroke when ischemic stroke and cholesterol are unrelated. It appears likely that some of the beneficial effects of statins in ischemic stroke are attributable to the pleiotropic effects of statins on endothelial function and fibrinolytic pathways.
The Journal of Clinical Investigation