Muscle coenzyme Q10 level in statin-related myopathy
C Lamperti, AB Naini, V Lucchini, A Prelle… - Archives of …, 2005 - jamanetwork.com
Background Statin drugs (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors)
reduce the level of cholesterol by inhibiting the synthesis of mevalonate, an intermediary in
the cholesterol biosynthetic pathway. Use of statin drugs has been associated with a variety
of skeletal muscle–related complaints. Coenzyme Q 10 (CoQ 10), a component of the
mitochondrial respiratory chain, is also synthesized from mevalonate, and decreased
muscle CoQ 10 concentration may have a role in the pathogenesis of statin drug–related …
reduce the level of cholesterol by inhibiting the synthesis of mevalonate, an intermediary in
the cholesterol biosynthetic pathway. Use of statin drugs has been associated with a variety
of skeletal muscle–related complaints. Coenzyme Q 10 (CoQ 10), a component of the
mitochondrial respiratory chain, is also synthesized from mevalonate, and decreased
muscle CoQ 10 concentration may have a role in the pathogenesis of statin drug–related …