The mechanism of the muscle toxicity associated with lipid-lowering therapy remains
obscure. Pathological and biochemical findings in patients with statin myotoxicity suggest
impaired fatty acid oxidation. Exhaled gas analysis can be used to assess substrate
utilization including fatty acid oxidation. In order to determine if muscle toxicity due to lipid-
lowering therapy might be related to abnormalities in lipid oxidation, exhaled gas analysis
was performed in the fasted state on 11 patients subsequent to statin-associated myositis …