Sub types of α2-adrenoceptors: Pharmacological and molecular biological evidence converg

DB Bylund - Trends in pharmacological sciences, 1988 - cell.com
DB Bylund
Trends in pharmacological sciences, 1988cell.com
A review of the available evidence indicates that oc2-adrenoceptors are not a homogeneous
class of receptors, but can be subdivided into several subtypes based on their
pharmacological characteristics. The recent cloning of t,~ e DNA for two ec2-receptor
subtypes;'rovides an independent validation of the pharmacological data. David Bylund
argues that the combination of cloning and pharmacological techniques should soon
provide for a consistent classification scheme for ec2-adrenoceptor subtypes in particular …
A review of the available evidence indicates that oc2-adrenoceptors are not a homogeneous class of receptors, but can be subdivided into several subtypes based on their pharmacological characteristics. The recent cloning of t,~ e DNA for two ec2-receptor subtypes;'rovides an independent validation of the pharmacological data. David Bylund argues that the combination of cloning and pharmacological techniques should soon provide for a consistent classification scheme for ec2-adrenoceptor subtypes in particular, and for adrenoceptors in general.
The recent proliferation of subtypes of receptors for neurotransmitters and hormones has been a matter of considerable debate in recent years. The advent of the radioligand binding assay some 15 years ago made the screening of many drugs relatively ea.~ y and resulted in the identific_ation of additional pharmacological subtypes for many receptors. However, many investigators have been reluctam'to accept receptor subtypes when the only evidence was the differential potencies of
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